TURALIO NOW APPROVED Introducing the first and only prescription medicine used to treat adult patients who have symptomatic tenosynovial giant cell tumor (TGCT)

What is TURALIO?

TURALIO is a prescription medicine used to treat certain adults who have tenosynovial giant cell tumor (TGCT) that is not likely to improve with surgery. TGCT is also known as giant cell tumor of the tendon sheath (GCT-TS) or pigmented villonodular synovitis (PVNS).

It is not known if TURALIO is safe and effective in children.

To learn more about the approval of TURALIO™ (pexidartinib), see the press release here.

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TGCT Treatment Centers Locate doctors that can prescribe TURALIO and other centers that may treat TGCT. FIND TGCT TREATMENT CENTERS NOW

Click on each joint to learn more about TGCT.
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X DIFFUSE

10%-20% of TGCT cases

Diffuse TGCT can spread throughout the joint. It is usually found in or around large joints, like knees or hips. Diffuse tumors are usually large (>5 cm) and have poorly defined borders.

Learn more >
  • Can spread throughout the entire joint.
  • Usually affects larger joints, like knees or hips.
  • May be painful and can limit movement. Can be difficult to remove completely with surgery and often grows back. This may result in multiple surgeries that can cause scar tissue to build up or damage cartilage around the joint, leading to osteoarthritis.
  • May lead to the need for joint replacement surgery in severe cases.
X DIFFUSE

10%-20% of TGCT cases

Diffuse TGCT can spread throughout the joint. It is usually found in or around large joints, like knees or hips. Diffuse tumors are usually large (>5 cm) and have poorly defined borders.

Learn more >
  • Can spread throughout the entire joint.
  • Usually affects larger joints, like knees or hips.
  • May be painful and can limit movement. Can be difficult to remove completely with surgery and often grows back. This may result in multiple surgeries that can cause scar tissue to build up or damage cartilage around the joint, leading to osteoarthritis.
  • May lead to the need for joint replacement surgery in severe cases.
X DIFFUSE

10%-20% of TGCT cases

Diffuse TGCT can spread throughout the joint. It is usually found in or around large joints, like knees or hips. Diffuse tumors are usually large (>5 cm) and have poorly defined borders.

Learn more >
  • Can spread throughout the entire joint.
  • Usually affects larger joints, like knees or hips.
  • May be painful and can limit movement. Can be difficult to remove completely with surgery and often grows back. This may result in multiple surgeries that can cause scar tissue to build up or damage cartilage around the joint, leading to osteoarthritis.
  • May lead to the need for joint replacement surgery in severe cases.
X LOCALIZED

80%-90% of TGCT cases

Localized TGCT, the more common type, is usually limited to a specific part of the joint and the tumor edges are well defined. It is typically found in or around small joints, like those of the hands and feet.

Learn more >
  • Is the more common form of TGCT.
  • Is limited (localized) to a specific portion of the joint.
  • Usually affects smaller joints, like those of the hands and feet.
  • May cause swelling and pain.
  • Usually can be removed with surgery, though tumors may sometimes grow back.
  • May require additional surgery to remove new growth.
X LOCALIZED

80%-90% of TGCT cases

Localized TGCT, the more common type, is usually limited to a specific part of the joint and the tumor edges are well defined. It is typically found in or around small joints, like those of the hands and feet.

Learn more >
  • Is the more common form of TGCT.
  • Is limited (localized) to a specific portion of the joint.
  • Usually affects smaller joints, like those of the hands and feet.
  • May cause swelling and pain.
  • Usually can be removed with surgery, though tumors may sometimes grow back.
  • May require additional surgery to remove new growth.
X LOCALIZED

80%-90% of TGCT cases

Localized TGCT, the more common type, is usually limited to a specific part of the joint and the tumor edges are well defined. It is typically found in or around small joints, like those of the hands and feet.

Learn more >
  • Is the more common form of TGCT.
  • Is limited (localized) to a specific portion of the joint.
  • Usually affects smaller joints, like those of the hands and feet.
  • May cause swelling and pain.
  • Usually can be removed with surgery, though tumors may sometimes grow back.
  • May require additional surgery to remove new growth.
X DIFFUSE

10%-20% of TGCT cases

Diffuse TGCT can spread throughout the joint. It is usually found in or around large joints, like knees or hips. Diffuse tumors are usually large (>5 cm) and have poorly defined borders.

Learn more >
  • Can spread throughout the entire joint.
  • Usually affects larger joints, like knees or hips.
  • May be painful and can limit movement. Can be difficult to remove completely with surgery and often grows back. This may result in multiple surgeries that can cause scar tissue to build up or damage cartilage around the joint, leading to osteoarthritis.
  • May lead to the need for joint replacement surgery in severe cases.
X LOCALIZED

80%-90% of TGCT cases

Localized TGCT, the more common type, is usually limited to a specific part of the joint and the tumor edges are well defined. It is typically found in or around small joints, like those of the hands and feet.

Learn more >
  • Is the more common form of TGCT.
  • Is limited (localized) to a specific portion of the joint.
  • Usually affects smaller joints, like those of the hands and feet.
  • May cause swelling and pain.
  • Usually can be removed with surgery, though tumors may sometimes grow back.
  • May require additional surgery to remove new growth.
X DIFFUSE

10%-20% of TGCT cases

Diffuse TGCT, can spread throughout the joint. It is usually found in or around large joints, like knees or hips. Diffuse tumors are usually large (>5 cm) and have poorly defined borders.

Learn more >
  • Can spread throughout the entire joint.
  • Usually affects larger joints, like knees or hips.
  • May be painful and can limit movement. Can be difficult to remove completely with surgery and often grows back. This may result in multiple surgeries that can cause scar tissue to build up or damage cartilage around the joint, leading to osteoarthritis.
  • May lead to the need for joint replacement surgery in severe cases.

The circles represent common locations of diffuse and localized TGCT. A larger circle indicates a higher occurrence at the site. Typically, only one joint is affected at a time.